WebMay 1, 2024 · Doxorubicin can cause p38 activation in cardiomyocytes through negative modulation of the PI3K pathway and promotion of an atrophy gene program, 30 and p38 MAPK activation can have a direct negative inotropic effect at the level of myofilament Ca 2+ sensitivity. 59 Activation of p38 promotes increased energy expenditure and … WebDOXORUBICIN PHARMACOKINETICS PATHWAY (PW:0001565) View Ontology Report Description: Doxorubucin (DOX, trade name Adriamycin) is an anthracycline derived from Streptomyces bacterium Streptomyces peucetius var. caesius.DOX is used in the treatment of several solid cancers, leukemia and lymphomas.
Frontiers Discovery of Novel Doxorubicin Metabolites in MCF7 ...
Web1. INTRODUCTION. Isolated from streptomyces peucetius, doxorubicin (DOX) is an effective antibiotic in treatment of various tumors. 1 However, a large dosage use of DOX results in hard‐to‐treat injuries in the myocardium, which may bring about heart dysfunction, severe heart failure, and even death, especially among children and adolescents. 2 DOX … WebJan 21, 2024 · Doxorubicin is an effective chemotherapeutic agent prescribed to treat solid tumors (e.g., ovary, breast, and gastrointestinal cancers). This anti-cancer drug has … christus st vincent ob gyn
Blocking the CXCL1-CXCR2 axis enhances the effects of doxorubicin …
WebDoxorubicin (DXR) is a 14- hydroxylated version of daunorubicin, the immediate precursor of DXR in its biosynthetic pathway. Daunorubicin is more abundantly found as a natural product because it is produced by a number of different wild type strains of streptomyces. WebDec 15, 2004 · The present study investigates the role of the p53/p21 system in the response of human colon carcinoma cells to treatment with the cytotoxic agent … WebDoxorubicin-induced mitophagy and mitochondrial damage is associated with dysregulation of the PINK1/parkin pathway The usefulness of doxorubicin (DOX), a potent anticancer agent, is limited by its cardiotoxicity. Mitochondria play a central role in DOX-induced cardiotoxicity though the precise mechanisms are still obscure. christus st vincent orthopaedics