WebAllovalency revisited: An analysis of multisite phosphorylation and substrate rebinding Locasale, Jason W. Abstract. The utilization of multiple phosphorylation sites in regulating a biological response is ubiquitous in cell signaling. If each site contributes an additional, equivalent binding site, then one consequence of an increase in the ... WebJun 8, 2024 · Allovalency is different than avidity and refers to the situation where more and identical receptor-binding sites (n) are positioned in tandem on an IDP, Fig. 1c. The concept was developed by Klein, Pawson and Tyers in 2003 [ 22 ] and discussed and elaborated by others [ 23 , 29 ].
Avalency - Wikipedia
WebOct 1, 2003 · The allovalency model suggests that a previously undescribed mechanism may underlie certain cooperative interactions. The widespread occurrence of flexible polyvalent ligands in biological systems ... WebJun 15, 2007 · Title: Allovalency revisited: an analysis of multisite phosphorylation and substrate rebinding. Authors: Jason W. Locasale. Download PDF Abstract: The utilization of multiple phosphorylation sites in regulating a biological response is ubiquitous in cell signaling. If each site contributes an additional, equivalent binding site, then one ... gummy bears on clear liquid diet
Allovalency observed by transferred NOE: interactions of sulfated ...
WebMar 21, 2008 · The utilization of multiple phosphorylation sites in regulating a biological response is ubiquitous in cell signaling. If each site contributes an additional, equivalent binding site, then one cons... Weblar manner exhibiting allovalency. Allovalency is defined as the presence of multiple, identical determi-nants arranged in tandem on an intrinsically disor-dered polypeptide that compete for binding to a receptor-binding site that can accommodate only one The FEBS Journal 288 (2024) 1648–1663 ª 2024 Federation of European Biochemical ... Weba. Containing antigens from a single strain of a microorganism or virus. Used of a vaccine or serum. b. Having only one site of attachment. Used of an antibody or antigen. 2. … bowling green state university handshake